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Some Men Shed HIV in Semen Despite ART, Linked to Herpesvirus Coinfection

About 10% of gay men in a U.S. study had detectable HIV in their semen despite suppression of blood plasma viral load with antiretroviral therapy (ART), which has implications for HIV transmission, according to a study described in the April 17, 2013, advance online edition of Clinical Infectious Diseases. Having a low but detectable blood viral load and coinfection with cytomegalovirus or Epstein-Barr virus were associated with increased likelihood of semen HIV shedding.

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NIH Halts HIV Vaccine Study Due to Lack of Effectiveness

 

The National Institutes of Institute of Allergy and Infectious Diseasesannounced this week that it will halt administration of an experimental HIV vaccine in the HVTN 505 trial, after an interim data analysis found that it neither prevented new HIV infections nor lowered viral load among people who did become infected.

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Study Suggests Why Adult Circumcision Helps Prevent HIV Infection

Removal of the foreskin reduces the presence of anaerobic bacteria, which enables the immune system maintain control of sexually transmitted pathogens such as HIV, according to a study from Uganda reported in the April 16, 2013, edition of the open-access online journal mBio, published by the American Society for Microbiology (ASM).

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Reformulated Tenofovir Gel Found Safe and Acceptable for Anal Sex

 

Men and women found a microbicide gel containing 1% tenofovir -- which has been shown to reduce the risk of HIV infection during vaginal sex -- to also be acceptable for anal use after it was reformulated to reduce the amount of an ingredient that led to irritation in an earlier study, according to a report in the April 3, 2013, edition of PLoS ONE.

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CROI 2013: Women's PrEP Trial Does Not Show HIV Risk Reduction [VIDEO]

Long-awaited results from the VOICE trial of post-exposure prophylaxis (PrEP) for women in Africa, presented at the recent 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta, was not able to show that daily oral tenofovir plus emtricitabine (the drugs in Truvada) could lower the risk of HIV acquisition.

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